Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add filters








Language
Year range
1.
Braz. j. pharm. sci ; 52(3): 527-544, July-Sept. 2016. tab, graf
Article in English | LILACS | ID: biblio-828267

ABSTRACT

ABSTRACT The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of drugs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed.


Subject(s)
Skin Absorption/drug effects , Pharmaceutical Preparations/administration & dosage , Skin Absorption/drug effects , Skin Absorption/immunology
2.
RBCF, Rev. bras. ciênc. farm. (Impr.) ; 38(1): 55-62, jan.-mar. 2002. ilus, tab, graf
Article in English | LILACS | ID: lil-317068

ABSTRACT

A liberaçäo transdérmica de muitos fármacos é dificultada pelas características de barreira do estrato córneo. Promotores químicos de absorçäo cutânea säo capazes de interagir com os constituintes do estrato córneo, induzindo aumento temporário e reversível na permeabilidade da pele. O objetivo deste trabalho foi avaliar a influência de sistemas monoleína (monoleato de glicerol)/solventes na absorçäo percutânea de um fármaco lipofílico (a progesterona), através do estrato córneo de camundongos sem pelo, bem como o efeito da monoleína nas características estruturais do estrato córneo, por meio de microscopia eletrônica de varredura...


Subject(s)
Animals , Rats , Skin Absorption/physiology , Skin Absorption/immunology , In Vitro Techniques , Pharmaceutical Preparations/analysis , Progesterone , Skin Physiological Phenomena , Fluorescein/pharmacology , Microscopy, Electron, Scanning , Microscopy, Confocal , Permeability
SELECTION OF CITATIONS
SEARCH DETAIL